The apparent incongruence found when analyzing sequences of the eIF(iso)4E factors from permissive N. clevelandii (S50 and S147) and non-permissive A. thaliana (A48 and K149) and C. foetidum (S49 and R146) species (Figure 5A) could be explained by the fact that it is the functional capacity, rather than the primary sequence of the eIF4E/(iso)4E plant factors, what decides whether a successful infection takes place. The gene discussed is EIF4E; the disease is infection.