Using RNA in situ hybridization technique to localize interleukins (IL1β, IL-6, IL-8, and IL-10 mRNA) in low-grade and high-grade prostate cancer in African American men and European American men, Maynard et al. found that IL-8 was the most abundantly expressed and there was no difference between races [61]. This evidence concerns the gene IL6 and Familial prostate cancer.