HSF1 and Alzheimer disease: In that pathway, its downstream targets, transcription factor heat shock factor 1 (HSF-1) and abnormal dauer formation 16 (DAF-16/Forkhead box O (FOXO) homolog), can also play a regulatory role in protecting Caenorhabditis elegans from toxic amyloid-β (Aβ) aggregation, a putative etiology of AD [6,7].