Moreover, there exists cross-talk between activation of the Nrf-2 system and anti-inflammatory effects via interactions with NF-κB, through identification of NF-κB binding sites in the promoter region of the Nrf-2 gene [45,46]; this cross-talk showed good efficacy in many models of peripheral neuropathy [47,48]. This evidence concerns the gene NFE2L2 and peripheral neuropathy.