Satterfield et al. [16] evidenced that it is particularly the SNP rs1800629 of TNF-α that determines a level of resilience to psychomotor vigilance performance impairment due to TSD, whereas no significant association was found with ADORA2A, PER3, TLR4, and a gene polymorphism located in the MHC nearby that of TNFα, DQB1*0602. The gene discussed is TNF; the disease is Tay-Sachs disease.