Apart from E6 and E7, c-Myc (MYC) is also reported to recruit DNA methyltransferase 3 alpha (DNMT3A) [73], and the MYC-associated genetic network is reported to be activated in HPV-associated HNSCC [74,75,76] (Figure 2). The gene discussed is DNMT3A; the disease is head and neck squamous cell carcinoma.