IL-1β is a potent proinflammatory cytokine whose upregulation induces angiogenesis and neuroinflammation [38] and has been reported to be an inflammatory mediator in the development of wet AMD, since these patients have shown increased plasma and vitreous levels of this cytokine [39,40]; in contrast, in animal models, its inhibition significantly reduced the development of subretinal neovascularization and has been shown to prevent choroidal neovascularization [39,41,42]. The gene discussed is IL1B; the disease is wet macular degeneration.