Moreover, considering the role that CSB has in transcription-coupled repair of bulky DNA adducts produced by platinum-based chemotherapeutic agents used in cancer therapy, and the fact that the silencing of CSB by RNA interference has been proven to increase the sensitivity of tumor cells to the chemotherapeutic agent cisplatin, one can acknowledge the important effect that the silencing of CSB may confer in minimizing the chemotherapeutic dose required to induce apoptosis, thereby reducing chemotherapy side effects [91,107]. The gene discussed is ERCC6; the disease is cancer.