ERCC6 and lung carcinoma: Such examples include rs3793784: C > G (NC_000010.11:g.49539493G > C), an ERCC6 variant, which alters its transcriptional activity and may increase lung cancer susceptibility, as well as rs4253002: G > A (NC_000010.11:g.49539292C > T) and rs4253212: G > A (NC_000010.11:g.49470166G > A), SNPs which are associated with toxicities (gastrointestinal toxicity and neutropenia, respectively) after platinum-based chemotherapy in patients with advanced non-small cell lung cancer [108,109].