Very few studies on associations of AD with HLA class I genes have been published thus far: genome-wide association studies indicating polymorphisms in the HLA class I region [7,8,9], description of direct associations of HLA class I alleles with AD [10,11] and demonstration of HLA-A*02:01-restricted response of CD8+ T cells against autoallergen [12]. Here, HLA-A is linked to Alzheimer disease.