The CXCL-12-CXCR-4 axis also orchestrates the recruitment of TAMs via endothelial barrier into hypoxic tumor regions [98], and targeting CXCL-12-CXCR-4 axis alleviates tumor burden and metastatic susceptibility in breast, prostate, and ovarian cancer models by averting TAM infiltration [99,100]. Here, CXCL12 is linked to ovarian carcinoma.