In the present study, direct comparison as well as univariate analyses also showed that patients with the monophasic course of TBE were older and had a higher proportion of underlying diseases than those with the biphasic course of the disease, and that they had longer duration of illness prior to diagnosis and more pronounced disruption of the blood–brain barrier as indicated with higher albumin and IgG indexes, all of which could contribute to greater disease severity. Here, ALB is linked to tick-borne encephalitis.