Several factors were significantly associated with monophasic course of TBE, including age of patients (OR = 1.02), the presence of underlying illness (OR = 1.87), previous vaccination against TBE (OR = 8.38), duration of neurologic involvement before CSF examination (OR = 1.34), severity of illness according to severity score (OR = 1.02), albumin quotient (OR = 1.58), IgG quotient (OR = 1.48), and IgG antibody levels against TBEV in serum (OR = 1.19). This evidence concerns the gene ALB and tick-borne encephalitis.