STAT3 and gastric cancer: Activated ROS production also plays a role in JAK2/STAT3 signaling suppression and subsequent apoptosis induction; for example, Cao et al. demonstrated that CYT997, a novel synthetic microtubule-disrupting agent, through the upregulation of mitochondrial ROS, triggers protective autophagy and inhibits the JAK2/STAT3 pathway, inducing gap 2 (G2)/mitosis (M) arrest and apoptosis in gastric cancer cells [88].