Silencing PVT1 expression in renal cancer cell lines through miR-16-5p transfection restored PVT1 normal expression levels, halted cell overproliferation, increased E-cadherin expression, and reduced expression of mesenchymal markers N-cadherin and vimentin, while promoting caspase-3 dependent apoptosis [171]. Here, PVT1 is linked to renal carcinoma.