Similar mTOR-driven metabolic regulation was found in another RCC type in a kidney-specific Cre (KspCre) Tsc1 mutant restricted to a segment of renal tubule; in this case, mTOR has been found to downregulate the TCA cycle enzyme fumarate hydratase leading to fumarate accumulation, and driving tumor cell progression [46,116]. Here, MTOR is linked to renal cell adenocarcinoma.