Central nervous system (CNS) tumor with BCL6-corepressor internal tandem duplication (CNS-BCOR ITD) is a malignant entity initially identified by Sturm et al. [1], and more recently proposed as a distinct CNS tumor type by the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT) [2,3]. The gene discussed is BCL6; the disease is central nervous system neoplasm.