TUG1 and neoplasm: The results of a study by Zhao et al. [110] show that TUG1 could serve as a molecular sponge of miR-140-5p to abolish its repressive effect on Profilin 2 (PFN2), thus markedly increasing cell proliferation, migration, invasion capacity in human OS cell lines and, in addition to TUG1 silencing, could decrease tumor growth in OS xenograft models.