The results of a study by Zhao et al. [110] show that TUG1 could serve as a molecular sponge of miR-140-5p to abolish its repressive effect on Profilin 2 (PFN2), thus markedly increasing cell proliferation, migration, invasion capacity in human OS cell lines and, in addition to TUG1 silencing, could decrease tumor growth in OS xenograft models. This evidence concerns the gene PFN2 and neoplasm.