The proliferative effect induced by hyperglycemia occurs as a result of overexpression of the following: glucose receptors (GLUT-1, GLUT-3) in tumor cells, protein kinase C (PKC-α), peroxisome proliferator-activated receptor (PPAR α and γ), and epithelial growth factor (EGF) [83]. This evidence concerns the gene SLC2A3 and neoplasm.