TP53 and lung cancer: Klein A et al. conducted a study between 2004 and 2011 and found that prostate cancer risk for healthy men was markedly increased upon supplementation with 400 IU/day of vitamin E supplement [276], whereas VI Sayin et al. clarified that supplementation with the antioxidants N-acetylcysteine (NAC) and vitamin E noticeably enhances human lung cancer cells proliferation and tumor progression in mice with B-RAF- and K-RAS-induced lung cancer via decreasing ROS, DNA damage, and p53 levels.