The activation of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and the inactivation of phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) are considered the major alterations of the PI3K pathway in breast cancer, head and neck cancer, and gynecological and gastrointestinal tumors [23]. Here, PIK3R1 is linked to breast cancer.