In our studies, the difference in sensitivity of A549 and H1299 cells to ML385 (NRF2 inhibition) was only significant when cells were also treated with artesunate, Figure 5 and Supplemental Figure S2, which could indicate cooperation between artesunate and ML385 in KEAP1 mutant lung cancer cells. The gene discussed is KEAP1; the disease is lung carcinoma.