Indeed, it has been reported that patients with hypertension and treated with ACE1 or angiotensin receptor blocker (ARB) medications, targeting the Renin-Angiotensin System (RAS), may have the ACE1/ACE2 ratio elevated, leading potentially to a worsening of SARS-CoV-2 infection [44]. This evidence concerns the gene ACE2 and hypertensive disorder.