DUX4 and sarcoma: EwS-related entities may differ radiologically from classical EwS, e.g., small round cell sarcomas (SRCS) with CIC-DUX4 fusion often present as necrotic and hypermetabolic soft-tissue masses while SRCS with BCOR-CCNB3 translocations are vascular bone lesions with necrosis at imaging (please see section “Round cell sarcoma with non-ETS-fusions and CIC/BCOR-rearranged sarcoma”) [27].