CTLA4 and colorectal carcinoma: The colonic increase in Foxp3(+) cells is significantly higher in patients with CRC, compared to healthy controls or patients with inflammatory bowel disease [34], and Treg cells with a higher expression of several molecules that correlate with suppression, such as Tim-3, LAG-3, TGF-β, IL-10, CD25, and CTLA-4, are observed in CRC patients [32].