However, remarkably, a significant increase in the frequency of Treg cells was observed at Day 68, compared to the control and STAT6−/− AOM/DSS mice (9.44 ± 0.1 vs. 19.85 ± 3.8, p < 0.05; 12.7 ± 0.1 vs. 19.85 ± 3.8, p < 0.05) (Figure 1C–F). Here, STAT6 is linked to infectious otitis media.