STAT6 and infectious otitis media: In contrast, we found an increased Treg frequency in the blood and spleen of STAT6−/− AOM/DSS animals at Day 20 (early stages of tumor development), compared to the control and WT AOM/DSS mice (17.5 ± 1 vs. 9.44 ± 0.1, p < 0.05; 17.5 ± 1 vs. 9.8 ± 3.3, p < 0.05) (Figure 1C–F).