Our analysis revealed a significant increased accumulation of Foxp3+ cells in the colon of the STAT6−/− AOM/DSS mice, compared to the WT AOM/DSS animals, at Day 20 of the CAC progression (27.8 ± 7.8 vs. 0.2 ± 0.05, p < 0.001) (Figure 2A,B). This evidence concerns the gene STAT6 and infectious otitis media.