In contrast, during the advanced stages of tumor development (Day 68), the Foxp3+ cells were significantly higher in the tumor-bearing WT mice, compared to the STAT6−/− AOM/DSS animals, (30.6 ± 7.3 vs. 5.6 ± 4.2, p < 0.001) (Figure 2A,B). The gene discussed is STAT6; the disease is infectious otitis media.