As shown in Figure 1G,H, at Day 20 of the CAC progression, we observed a higher expression of TGF-β and IL-10 cytokines in CD4+CD25+Foxp3+ cells (Figure 1H) from STAT6−/− AOM/DSS compared to WT AOM/DSS mice. The gene discussed is TGFB1; the disease is infectious otitis media.