STAT6 and infectious otitis media: We observed a significant increase levels of TGF-β transcripts in the colons of the STAT6−/− AOM/DSS mice, compared to the WT AOM/DSS mice, at Day 20 (2.4 ± 0.5 vs. 1.13 ± 0.71; p < 0.001) (Figure 2D).