STAT6 and infectious otitis media: On the contrary, the expression of TGF-β mRNA was increased in the colons of the tumor-bearing WT mice, compared to the STAT6−/− AOM/DSS animals, at Day 68 of the CAC progression (2.1 ± 0.2 vs. 0.5 ± 0.4; p < 0.01) (Figure 2D).