MXRA5 and colorectal cancer: A potential age-by-sex-related CpG, cg26738106 (chrX:3265038, TSS1500 of MXRA5), detected in the discovery set (beta = 0.09 and p = 3.0 × 10−9 in Model 2.2) was associated with colorectal cancer risk with OR = 0.58 (95% CI: 0.44–0.77), p = 0.0001 in Model 3.1, and OR = 0.59 (95% CI: 0.44–0.78), p = 0.0002 after adjustment for smoking, alcohol consumption and BMI (Model 3.2).