One age-by-sex-associated CpG cg12054453 (chr17:57915717) in the gene body of TMEM49 was associated with survival of cancer overall (p < 0.001) with HR = 0.88 (95% CI: 0.83–0.93), p = 2.3 × 10−6 in Model 4.1 and HR = 0.91 (95% CI: 0.86–0.96), p = 7.7 × 10−4 after adjustment for lifestyle-related confounders (Model 4.2). This evidence concerns the gene VMP1 and cancer.