Based on our findings, MAI stimulation of the HT7 acupoint significantly (1) decreased the plasma CORT level, (2) decreased the anxiety index, (3) decreased aversive 22-kHz USVs, (4) increased the levels of mBDNF and phosphorylated TrkB in the amygdala, and (5) decreased CRH levels in the rat PVN induced by the repeated injection of ETOH for 14 days. The gene discussed is CRH; the disease is Anxiety.