In mouse models of NPC, total spleen, brain, and liver gene expression profiles pointed to increased uptake (msr1, fabp5), more lysosomes (ctsb, ctss, ctsb, hexb, man2b1, and lyz1&2), lipid droplets (plin3, plin4), and innate immune activation, including macrophage involvement [37]. This evidence concerns the gene CTSB and nasopharyngeal carcinoma.