A great majority of MEN1 patients develop, during their life, multiple pancreatic microadenomas (less than 0.5 cm in diameter), mostly NF-pNETs (approximately 50% of cases) [4], insulinomas (7–31% of cases) [5], and gastrinomas (about 5% of cases) [6]. This evidence concerns the gene MEN1 and pancreatic insulinoma.