MEN1 and neoplasm: The CASP8 gene encodes the caspase 8 protein, which activates apoptosis; the hypermethylation of CASP8 promoter, consequent to the loss of menin function and H3K4me3, silences the expression of the gene and may have a role in development and progression of MEN1-mutated pNETs by preventing apoptosis of tumor cells, as previously described in other human tumor types [35].