MEN1 and pancreatic insulinoma: Treatment of the rat insulinoma cell line, INS-1, knocked out for Men1 or Daxx, with Thiorphan, an MME inhibitor, was shown to repress cell proliferation at different time points in a dose-dependent manner [25], indicating this small molecule as a promising drug for the control of tumor growth in pNETs with MEN1 and/or DAXX mutations.