The MEN1 gene has been found to be the most common somatically mutated gene in sporadic pNETs (44% of total cases, 30% of NF-pNETs, 7% of insulinomas, 36% of gastrinomas, 67% of glucagonomas, and 44% of VIPomas) [9,16], and LOH at 11q13 or somatic MEN1 mutations manifest in up to 46% of these tumors (about 39% of NF-pNETs and 15–20% of gastrinomas and insulinomas), independent of the tumor stage [20,21,22]. Here, MEN1 is linked to pancreatic insulinoma.