IGF2BP2 and type 2 diabetes mellitus: Many of these target genes were linked to type 2 diabetes and beta cell functions, with the Insulin -like Growth Factor 2 mRNA Binding Protein 2 (Igf2bp2) gene, encoding the insulin-like growth factor 2 mRNA binding protein 2, being one of the most downregulated by the H3K4me3 loss.