However, tumor cells resist cell death through evolving multiple strategies to attenuate or circumvent apoptosis, including short-circuiting the extrinsic apoptosis pathway which is activated by cell death receptors upon binding to cognate ligands [2], such as the Fas ligand (FasL/Apo1L/CD95L), Apo 3 ligand (Apo3L), TNF-alpha (TNFα), and TNF-related apoptosis-inducing ligand (TRAIL, also designated as TNFSF10 and APO2L) [3]. The gene discussed is TNFSF10; the disease is neoplasm.