Since the anti-apoptotic Bcl-2 family members play a critical role in determining GBM sensitivity to TRAIL-induced apoptosis, inhibitors of this family members (BH3-mimetics), such as ABT-737 [130] and ABT-199 [131], were found to cooperate with TRAIL to induce apoptosis in several GBM cell lines in a highly synergistic manner. This evidence concerns the gene BCL2 and glioblastoma.