Mechanistically, the inhibition of NF-κB reduces the recruitment of FADD and caspase-8 and formation of DISC upon stimulation of TRAIL receptors, which restrains the TRAIL-mediated activation of caspases, loss of mitochondrial potential, and cytochrome c release, resulting in decreased TRAIL-induced apoptosis in GBM cells [74]. The gene discussed is FADD; the disease is glioblastoma.