Moreover, the cellular FLICE ((Fas-associated death domain–like IL-1β–converting enzyme)) inhibitory protein (c-FLIP) competes with caspase-8 for binding to FADD and therefore suppresses DISC activation, and in human GBM, c-FLIP expression is upregulated to resist TRAIL-induced apoptosis [57]. This evidence concerns the gene CASP8 and glioblastoma.