TNFSF10 and glioblastoma: By developing a targeted iron oxide nanoparticle coated with chitosan-polyethylene glycol-polyethyleneimine copolymer and chlorotoxin, one study has found that this delivery system successfully delivers TRAIL into human GBM cells and induces secretion of TRAIL in vitro and in vivo, resulting in near-zero tumor growth and induces apoptosis in tumor tissue [110].