A recent study has shown that the depletion of eIF5B sensitizes GBM cells to TRAIL-induced apoptosis by inhibiting the translation of several mRNAs encoding the anti-apoptotic proteins XIAP, Bcl-xL, cIAP1, and c-FLIPS, indicating that eIF5B allows GBM cells to evade TRAIL-induced apoptosis by promoting the translation of pro-survival proteins [108]. This evidence concerns the gene CFLAR and glioblastoma.