Paradoxically, however, NF-κB inhibition enhances TRAIL-induced apoptosis in mouse embryonic fibroblasts and neuroblastoma cells [74,76] and is also implicated in lovastatin-sensitized TRAIL-induced apoptosis in resistant GBM cells via upregulation of TRAIL-R2 level [77]. The gene discussed is TNFRSF10B; the disease is glioblastoma.