For example, it has been proven that the knockdown of PIM kinases decreases phosphorylation of p62 and sensitizes TRAIL-induced apoptosis via enhanced caspase-8 recruitment to and activation at the DISC; in line with this, p62 ablation facilitates TRAIL-induced caspase-8 activation, revealing an inhibitory role of p62 in TRAIL-mediated apoptosis in GBM [90]. The gene discussed is CASP8; the disease is glioblastoma.