ANGPT1 and familial dilated cardiomyopathy: To evaluate whether the elevated plasma cGMP and Ang (1–7) levels seen in DCM mice on a LSD were linked to increase NO production, we snap-suppressed the NO system in a sub-group of DCM mice by a single bolus injection of potent NO synthase inhibitor L-NAME at a concentration that influences cGMP production without modulating BP, as previously reported [42].