To better understand the protective contribution of the ACE-2–Ang (1–7)–NO–cGMP axis on HF progression under restricted sodium consumption in DCM, the impact of antagonists of Ang (1–7) receptors MAS and AT2 (angiotensin II receptor types) [18,21,22,56] or Ang (1–7) administration should be explored. The gene discussed is AGTR2; the disease is familial dilated cardiomyopathy.