Once MDSCs are recruited to the HGG site their expansion and activation are tightly controlled by cytokines (IL-6, IL-10, TGF-β, M-CSF, GM-CSF, INFγ), chemokines (CCR2, and other factors (VEGF) secreted by tumor cells, T cells, microglia, and macrophages (Figure 2) [9,33,45]. This evidence concerns the gene CSF2 and neoplasm.