To find tumor-associated genetic and epigenetic changes in the A37-modifying enzymes TRIT1 and CDK5RAP1 (Figure 1A), we data-mined a collection of about 1000 human cancer cell lines in which the transcriptome, DNA methylation landscape, exome sequence, and gene copy number were available [22,23]. Here, CDK5RAP1 is linked to neoplasm.