HSPA5 and lymphoma: To investigate whether the expression of GRP78 was also upregulated in the EBV lytic cycle, two latently EBV-infected lymphoma cell lines including Akata(+) and P3HR1 were treated with sodium butyrate (SB) plus 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce the viral lytic replication.