PRKDC and cancer: A recently published study by Bensimon et al. applied quantitative phosphoproteomic technique and identified a novel c-MET phospho-site that bears as substrate for the DNA damage response (DDR) machinery including DNA-dependent protein kinase (DNA-PK), nuclear mitotic apparatus protein 1 (NUMA1) and checkpoint kinase 1 (CHEK1) in c-MET addicted cancer cell lines [58].