In addition to c-Met, other CSC markers like the adhesion and hyaluronic acid (HA)-binding protein CD44, the amino acid transporter LAT1/CD98, the glycoprotein prominin-1/CD133, and aldehyde dehydrogenase (ALDH) have been identified in HNSCC [13,33,34,35,36,37,38]. The gene discussed is PROM1; the disease is head and neck squamous cell carcinoma.