Out of the 892 people in the control group with no history of cancer of any type who were matched to the UC cohort 2:1 using age, sex, and smoking status, 216 (21.8%) had a variant in ADGRL2. Only 59.4% of UC individuals with ADGRL2 variants were smokers, a lower rate than the rest of the UC cohort (those harboring no ADGRL2 variants were 71.2% smokers). This evidence concerns the gene ADGRL2 and cancer.