ADGRL2, also called LPHH1, PLHN1, and LPHN2 is a G-protein coupled receptor that triggers exocytosis from neurons and neuroendocrine cells It had previously been found to be variably expressed in breast cancer cell lines [24] and silenced by epigenetic modifications in human gastric and colon cancers [25]. Here, ADGRL2 is linked to malignant colon neoplasm.