For the test for urothelial cancer incidence, comparing the control and case populations’ germline variants yielded one gene of suggestive significance, ADGRL2. 29.4% of UC patients in the Geisinger cohort had at least one germline variant in ADGRL2. In comparison, 24% of UC patients in another cohort were found to have a pathogenic germline variant in one of 17 genes previously known to predispose to cancer [23]. The gene discussed is ADGRL2; the disease is cancer.