This was corroborated by literature publishing that TNF-α, IL-1B, IL-6 and IL-18 also independently predicted the occurrence of PSD in the acute to subacute period [99,100], and elevated IL-6, IL-10 and TNF-α correlates with PSD at one to three months post stroke [91,98,101,102,103,104,105,106,107,108]. The gene discussed is IL18; the disease is stroke disorder.