Biasiolo et al. showed that lysed platelets and gel-filtered platelets from anticoagulated APS patients with a quiescent APS did not contain aCL antibodies or LAC activity, which would mean that the antibodies do not bind to platelets in circulation, but that the binding only occurs after the platelet is activated [61,62]. This evidence concerns the gene ACLY and autoimmune polyendocrinopathy.