However, it has been shown that active VWF is increased in various pathological conditions, for example, Von Willebrand disease type 2B, congenital/acquired thrombotic thrombocytopenic purpura (TTP), HELLP-syndrome (hemolysis, elevated liver enzymes and low platelets), malaria and APS [6]. The gene discussed is VWF; the disease is autoimmune polyendocrinopathy.