AHR and systemic lupus erythematosus: Here, we demonstrated that LPS activation followed by an Ahr agonist (a representative environmental stimulator) could induce late apoptosis in FcgRIIb−/− macrophages, but not in WT macrophages, which might accelerate activity of the lupus-like condition in FcgRIIb−/− mice through apoptosis-induced lupus exacerbation [78].