In addition, FcgRIIb-deficient (FcgRIIb−/−) mice demonstrate several characteristics of lupus (lupus-like condition) and have been used as a representative lupus model with the spontaneous development of anti-dsDNA, an important lupus autoantibody, as early as 16–24 weeks of age [33,34,35]. This evidence concerns the gene FCGR2B and systemic lupus erythematosus.