Since PBC is an autoimmune condition characterized by anti-mitochondrial autoantibodies (AMA) and high levels of immunoglobulin M (IgM), many immunosuppressive drugs were studied in PBC, including corticosteroid [54], azathioprine [55], cyclosporine [56], methotrexate [57], and mycophenolate mofetil [58]. The gene discussed is CD40LG; the disease is primary biliary cholangitis.