Mortalin depletion induced cell death and growth arrest in different human cell lines, including PTC (PTC-1 cell line), FTC (FTC133 cell line), and ATC (8505C, and C643 cell lines), and in mouse xenografts, revealing its role in promoting tumor cell survival and proliferation, which prompted the proposal of mortalin as therapeutic target [23,24]. This evidence concerns the gene HSPA9 and neoplasm.