The multivariate Cox regression model adjusted for prognostic factors including BMI, age at the time of diagnosis, staging system, intrinsic type, histological type, nodal involvement and tumour diameter showed a decrease in the risk of disease relapse with an increase in the concentration of SDF-1α and the number of circulating EPCs (HR = 5.1263; 95% CI, 1.0774–24.3915; p = 0.0400; HR = 7.9152; 95% CI, 1.2207- 51.3243; p = 0.0301, respectively) for DFS. Here, CXCL12 is linked to neoplasm.