This observation is also plausible with the high replication kinetics of SARS-CoV-2 and with the mechanism of action of hyperimmune plasma, considering that the blocking of viral replication during the initial phase of COVID-19 is also able to prevent the activation of inflammatory and coagulative cascade, often irreversible, which instead characterizes the advanced stage of the disease where, unfortunately, the viral anti-replicative activity of CP is, at that stage, ineffective. The gene discussed is CP; the disease is COVID-19.