PCSK9 inhibition with the PCSK9 inhibitor (PCSK9i) Prep2-8 trifluoroacetate salt significantly reduced levels of Phospho-NFκB/ NFκB and reactive microglia and astrocytic proliferation and hypertrophy in a rat model of cardiac ischemia/reperfusion injury [110]. Here, NFKB1 is linked to myocardial ischemia.