Among the IFN-induced proteins, many enzymes such as the RNA-dependent protein kinase (PKR), the 2′,5′-oligoadenylate (Oligo A) synthetase (OAS), the ribonuclease L (RNase L) and the myxovirus resistance guanosine triphosphatases (Mx GTPases) are upregulated and implicated in the protection against viral infection. Here, RNASEL is linked to viral infectious disease.