Another study reported that pDCs of SLE and antiphospholipid syndrome (APS) patients with high IFN signature displayed reduced expression of miR-361-5p, miR-128-3p and miR-181a-2-3 p compared to pDCs from patients without an IFN signature or healthy controls [87]. This evidence concerns the gene IFNA1 and autoimmune polyendocrinopathy.