Nevertheless, it was recognized that omalizumab, the IgE neutralizing antibody used for the treatment of allergic asthma, restores the virus-induced IFNα responses of pDCs in allergic patients upon rhinovirus infection [151] implying further that free IgE has a negative impact on the type I IFN production of pDCs (Table 2). This evidence concerns the gene IGHE and allergic asthma.