Primary SARS-CoV-2 respiratory infection induces systemic inflammation (CXCL10, IFN-ɤ, IL-1B, IL-6, IL-8, IL-17, TNF-α) that can impact the musculoskeletal system through the expression of hACE2-R and TMPRSS2 genes in various types of musculoskeletal cells, allowing direct viral infection. Here, TMPRSS2 is linked to viral infectious disease.