Through transfection experiments, computational prediction, and structure-based conformational and molecular dynamics simulation studies, it has been shown that the risk allele of rs11568818 exhibits increased binding affinity for cyclic AMP response element-binding protein (CREB), confers increased promoter activity, and enhances matrix metalloproteinase-7 (MMP7) expression, which aggravates hypertension (Figure 2) [132]. The gene discussed is MMP7; the disease is hypertensive disorder.