The risk allele diminishes androgen receptor (AR) occupancy, is associated with decreased H3K27ac levels, and downregulates the expression of VPS53, FAM57A, and GEMIN4, and the knockdown of VPS53, FAM57A, and GEMIN4 in prostate cancer cells results in an increase in cell viability [153]. Here, VPS53 is linked to Familial prostate cancer.