SIRPA and myelodysplastic syndrome: At least 10 therapeutics that block CD47:SIRPα interaction have been developed and are being studied in clinical trials, including magrolimab with completed Phase 1/2 in solid tumors and hematological malignancies and has entered Phase 3 in combination with Azacitidine for treatment of Myelodysplastic Syndrome (MDS) (clinical trials nr NCT04313881) [3,108] (Table 1).