PCSK9 and atherosclerosis: In the large Atherosclerosis Risk in Communities general population [37], the incidence of nonfatal myocardial infarction, fatal coronary artery disease or coronary revascularisation over a 15-year interval was analysed according to the presence or absence of sequence variants in the PCSK9 gene (PCSK9) associated with reduced plasma levels of LDL cholesterol.