ALOX12 and thrombocytosis disease: The mechanism of C. papaya leaf in increasing the platelet level has been associated with thrombocytosis activity, as the megakaryocytes genes, arachidonate 12-lipoxygenase (ALOX-12) and platelet-activating factor receptor (PTAFR), were found to be upregulated in dengue patients receiving C. papaya leaf juice [14].