Inhalational anesthetics, e.g., Isoflurane, exposure increased HIF-1α expression in a concentration- and time-dependent manner, and HIF-1α translocated from the cytoplasm to the nucleus as a transcription factor, resulting in various downstream effectors being activated and then, in turn, increased proliferation and invasion in prostate cancer cells [5]. This evidence concerns the gene HIF1A and Familial prostate cancer.