CFTR and exocrine pancreatic insufficiency: It has been reported that serum concentrations of linoleic acid and docosahexaenoic acid were significantly lower in patients who had severe CF transmembrane conductance regulator mutation (homozygotes for deltaF508 and heterozygotes/homozygotes for 394delTT) than the other groups (e.g., heterozygotes for deltaF508 CFTR mutation), excluding the impact of pancreatic insufficiency [30].