More recently, the identification of specific mutations in the IL36RN gene encoding the IL-36 receptor antagonist (IL-36Ra) have been linked to an autoinflammatory condition characterized by a severe form of GPP called “deficiency of interleukin-36-receptor antagonist” (DITRA); this highlights the importance of IL-36 family cytokines as critical mediators of psoriatic disease [14,15]. The gene discussed is IL1RL2; the disease is psoriasis 14, pustular.