Recently, we demonstrated that immune cell infiltration in AD-like skin lesions was substantially attenuated in Egr1-knockout mice, and the TNFα-induced expression of cytokines, including TSLP, IL-1β, IL-6, CXCL1, CCL2, and CCL5, was inhibited in response to EGR1 knockdown [42]. This evidence concerns the gene CCL2 and Alzheimer disease.